MLN Gene Summary [Human]

This gene encodes a small peptide hormone that is secreted by cells of the small intestine to regulate gastrointestinal contractions and motility. Proteolytic processing of the secreted protein produces the mature peptide and a byproduct referred to as motilin-associated peptide (MAP). Three transcript variants encoding different preproprotein isoforms but the same mature peptide have been found for this gene. [provided by RefSeq, May 2010]

Details

Type
Protein Coding
Official Symbol
MLN
Official Name
motilin [Source:HGNC Symbol;Acc:HGNC:7141]
Ensembl ID
ENSG00000096395
Bio databases IDs NCBI: 4295 Ensembl: ENSG00000096395
Aliases motilin, prepromotilin
Synonyms motilin
Species
Human, Homo sapiens
OrthologiesRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MLN often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • Motilin/ghrelin-associated peptide
  • G-protein-coupled receptor binding
  • protein binding
  • Motilin/ghrelin

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • insomnia
  • Crohn disease
  • hypersensitive reaction
  • alcohol use disorder
regulated by
regulates
role in cell
  • endocytosis by
  • tachyphylaxis in
  • stimulation

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Extracellular Space
  • plasma membrane fraction

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human MLN gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • signal transduction

Cellular Component

Where in the cell the gene product is active
  • extracellular region

Molecular Function

What the gene product does at the molecular level
  • protein binding
  • hormone activity
  • motilin receptor binding

Gene-Specific Assays for Results You Can Trust

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