APOL4 Gene Summary [Human]
This gene encodes a member of the apolipoprotein L family. The encoded protein may play a role in lipid exchange and transport throughout the body, as well as in reverse cholesterol transport from peripheral cells to the liver. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2020]
Details
| Type | Processed Transcript |
| Official Symbol | APOL4 |
| Official Name | apolipoprotein L4 [Source:HGNC Symbol;Acc:HGNC:14867] |
| Ensembl ID | ENSG00000100336 |
| Bio databases IDs | |
| Aliases | apolipoprotein L4 |
| Synonyms | apolipoprotein L4, APOL-IV |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human APOL4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Apolipoprotein L
Pathways
Biological processes and signaling networks where the APOL4 gene in human plays a role, providing insight into its function and relevance in health or disease.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- intracellular membrane-bounded organelle
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human APOL4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- lipid transport
- lipid metabolic process
- lipoprotein metabolic process
Cellular Component
Where in the cell the gene product is active
- extracellular space
- intracellular membrane-bounded organelle
Molecular Function
What the gene product does at the molecular level
- lipid binding