SIRPB1 Gene Summary [Human]
The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein was found to interact with TYROBP/DAP12, a protein bearing immunoreceptor tyrosine-based activation motifs. This protein was also reported to participate in the recruitment of tyrosine kinase SYK. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]
Details
| Type | Protein Coding |
| Official Symbol | SIRPB1 |
| Official Name | signal regulatory protein beta 1 [Source:HGNC Symbol;Acc:HGNC:15928] |
| Ensembl ID | ENSG00000101307 |
| Bio databases IDs | |
| Aliases | signal regulatory protein beta 1 |
| Synonyms | CD172b, LOC100653194, signal regulatory protein beta 1, signal regulatory protein β 1, SIRP-BETA-1, SIRP-β, SIRP-β-1 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SIRPB1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- Immunoglobulin C1-set domain
- immunoglobin constant region like domain
- Immunoglobulin V-Type
- immunoglobulin domain
- Immunoglobulin like
- Immunoglobulin I-set domain
- immunoglobulin variable region-like domain
- protein binding
- Immunoglobulin V-set domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- plasma membrane fraction
- cell surface
- cellular membrane
- secretory granule membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SIRPB1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of T cell activation
- signal transduction
- cell surface receptor signaling pathway
- positive regulation of phagocytosis
Cellular Component
Where in the cell the gene product is active
- secretory granule membrane
- membrane
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- protein binding