SYK Gene Summary [Human]
This gene encodes a member of the family of non-receptor type Tyr protein kinases. This protein is widely expressed in hematopoietic cells and is involved in coupling activated immunoreceptors to downstream signaling events that mediate diverse cellular responses, including proliferation, differentiation, and phagocytosis. It is thought to be a modulator of epithelial cell growth and a potential tumour suppressor in human breast carcinomas. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]
Details
| Type | Protein Coding |
| Official Symbol | SYK |
| Official Name | spleen associated tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:11491] |
| Ensembl ID | ENSG00000165025 |
| Bio databases IDs | |
| Aliases | spleen associated tyrosine kinase |
| Synonyms | IMD82, p72-Syk, Ptk72, spleen associated tyrosine kinase, spleen tyrosine kinase |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SYK often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine kinase
- protein kinase
- SYK interdomain B
- ATP binding
- protein-tyrosine kinase
- Protein kinase domain
- Src homology 2 (SH2) domain
- Tyrosine kinase, catalytic domain
- phosphatase binding
- ubiquitin protein ligase binding
- Protein kinase (unclassified specificity)
- protein kinase binding
- nuclear export signal
- catalytic domain
- Protein tyrosine and serine/threonine kinase
- SH2-domain binding
- interleukin-15 receptor binding
- enzyme binding
- central domain
- linker domain
- phosphotyrosine binding
- non-membrane spanning protein tyrosine kinase
- protein domain specific binding
- autophosphorylation site
- protein binding
- receptor binding
- Src-homology 2 binding domain
- phosphorylation site
- inter-SH2 domain
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- Protein Kinases, catalytic domain
- integrin binding
Pathways
Biological processes and signaling networks where the SYK gene in human plays a role, providing insight into its function and relevance in health or disease.
- B Cell Receptor Signaling
- CD28 Signaling in T Helper Cells
- Fc Epsilon RI Signaling
- Fcγ Receptor-mediated Phagocytosis in Macrophages and Monocytes
- FcγRIIB Signaling in B Lymphocytes
- GP6 Signaling Pathway
- IL-15 Production
- IL-15 Signaling
- IL-2 Signaling
- Natural Killer Cell Signaling
- Neuroinflammation Signaling Pathway
- p70S6K Signaling
- Phagosome Formation
- PI3K Signaling in B Lymphocytes
- Role of JAK1 and JAK3 in γc Cytokine Signaling
- Role of NFAT in Regulation of the Immune Response
- Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses
- Sperm Motility
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- rheumatoid arthritis
- infection
- hyperplasia
- metastasis
- non-insulin-dependent diabetes mellitus
- thrombocytopenia
- de novo acute myeloid leukemia
- CD30 positive anaplastic large cell lymphoma
- COVID-19
role in cell
- molecular cleavage in
- apoptosis
- cell death
- activation in
- loss in
- expression in
- cell viability
- signaling in
- binding in
- mitosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- nuclear fraction
- raft fractions
- membrane fraction
- cell cortex
- Nucleus
- Plasma Membrane
- centrosome
- cell-cell contacts
- cytosol
- membrane ruffles
- uropod
- plasma membrane projections
- microvilli
- cell membrane leading edge
- phagosomes
- centrosomal fraction
- cytoplasmic fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SYK gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- peptidyl-tyrosine phosphorylation
- positive regulation of mast cell degranulation
- interleukin-3-mediated signaling pathway
- macrophage activation involved in immune response
- neutrophil activation involved in immune response
- regulation of platelet aggregation
- blood vessel morphogenesis
- mast cell degranulation
- regulation of sequence-specific DNA binding transcription factor activity
- leukocyte activation involved in immune response
- serotonin secretion by platelet
- positive regulation of granulocyte macrophage colony-stimulating factor production
- regulation of superoxide anion generation
- lymph vessel development
- positive regulation of tumor necrosis factor production
- calcium-mediated signaling
- intracellular signal transduction
- positive regulation of mast cell cytokine production
- B cell differentiation
- positive regulation of receptor internalization
- positive regulation of type I interferon production
- adaptive immune response
- collagen-activated tyrosine kinase receptor signaling pathway
- defense response to bacterium
- regulation of neutrophil degranulation
- positive regulation of B cell differentiation
- organ morphogenesis
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
- positive regulation of interleukin-8 production
- positive regulation of bone resorption
- protein import into nucleus
- positive regulation of interleukin-3 production
- positive regulation of interleukin-6 production
- receptor internalization
- regulation of phagocytosis
- positive regulation of interleukin-4 production
- cellular response to low-density lipoprotein particle stimulus
- regulation of platelet activation
- positive regulation of monocyte chemotactic protein-1 production
- regulation of arachidonic acid secretion
- positive regulation of gamma-delta T cell differentiation
- Fc-epsilon receptor signaling pathway
- Fc-gamma receptor signaling pathway involved in phagocytosis
- beta selection
- protein phosphorylation
- positive regulation of alpha-beta T cell differentiation
- leukocyte cell-cell adhesion
- stimulatory C-type lectin receptor signaling pathway
- positive regulation of calcium-mediated signaling
- integrin-mediated signaling pathway
- angiogenesis
- positive regulation of alpha-beta T cell proliferation
- cellular response to lipid
- positive regulation of cell adhesion mediated by integrin
- platelet activation
- positive regulation of protein complex assembly
- positive regulation of peptidyl-tyrosine phosphorylation
- B cell receptor signaling pathway
- transmembrane receptor protein tyrosine kinase signaling pathway
- positive regulation of MAPK cascade
- negative regulation of inflammatory response to antigenic stimulus
- regulation of ERK1 and ERK2 cascade
- cell activation
- positive regulation of interleukin-12 production
- leukotriene biosynthetic process
- gamma-delta T cell differentiation
- innate immune response
- regulation of tumor necrosis factor-mediated signaling pathway
- cellular response to molecule of fungal origin
- cell differentiation
- neutrophil chemotaxis
- positive regulation of killing of cells of other organism
- positive regulation of interleukin-10 production
- positive regulation of superoxide anion generation
Cellular Component
Where in the cell the gene product is active
- nucleus
- early phagosome
- B cell receptor complex
- cytoplasm
- cytosol
- macromolecular complex
- T cell receptor complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- phosphatase binding
- protein kinase binding
- integrin binding
- protein kinase activity
- protein serine/threonine kinase activity
- SH2 domain binding
- receptor binding
- phosphotyrosine binding
- scaffold protein binding
- ATP binding
- protein tyrosine kinase activity
- protein binding
- interleukin-15 receptor binding
- non-membrane spanning protein tyrosine kinase activity
- phospholipase binding
- kinase activity
- Toll-like receptor binding