SIRPA Gene Summary [Human]
The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein can be phosphorylated by tyrosine kinases. The phospho-tyrosine residues of this PTP have been shown to recruit SH2 domain containing tyrosine phosphatases (PTP), and serve as substrates of PTPs. This protein was found to participate in signal transduction mediated by various growth factor receptors. CD47 has been demonstrated to be a ligand for this receptor protein. This gene and its product share very high similarity with several other members of the SIRP family. These related genes are located in close proximity to each other on chromosome 20p13. Multiple alternatively spliced transcript variants have been determined for this gene. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | SIRPA |
| Official Name | signal regulatory protein alpha [Source:HGNC Symbol;Acc:HGNC:9662] |
| Ensembl ID | ENSG00000198053 |
| Bio databases IDs | |
| Aliases | signal regulatory protein alpha |
| Synonyms | BIT, CD172A, Idd13.2, MFR, MYD-1, P84, PTP non-receptor type substrate 1, PTPNS1, P tyros subs 1, SHP-1, SHPS-1, signal-regulatory protein alpha, signal-regulatory protein α, SIRP, Sirp1 Alpha, Sirp1 α, SIRPA isoform 2, SIRPALPHA, SIRPα, Sirp-α-1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SIRPA often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GTPase regulator
- protein-tyrosine-phoshatase
- cell adhesion molecule binding
- Ig-like V domain
- phosphoprotein amino acid binding
- immunoglobin constant region like domain
- N-linked glycosylation site
- cytoplasmic domain
- immunoreceptor tyrosine-based inhibition motif
- Immunoglobulin like
- phosphatase
- intracellular domain
- immunoglobulin-like protein domain
- Immunoglobulin V-set domain
- transmembrane receptor
- extracellular domain
- Immunoglobulin C1-set domain
- protein kinase binding
- Immunoglobulin V-Type
- immunoglobulin domain
- protein phosphatase binding
- Immunoglobulin I-set domain
- antigen binding
- immunoglobulin variable region-like domain
- protein binding
- phosphotyrosine binding domain
- protein phosphatase inhibitor activity
- transmembrane domain
- cytosolic tail domain
Pathways
Biological processes and signaling networks where the SIRPA gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- experimental autoimmune encephalomyelitis
- hepatomegaly
- splenomegaly
- Alzheimer disease
- non-insulin-dependent diabetes mellitus
- neoplastic cell transformation
- cognitive impairment
- cardiac hypertrophy
- pancytopenia
- hemophagocytosis
role in cell
- expression in
- apoptosis
- phosphorylation in
- growth
- activation in
- survival
- tyrosine phosphorylation in
- proliferation
- binding in
- cell death
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- plasma membrane fraction
- soluble fraction
- membrane fraction
- Cytoplasm
- cell surface
- cell periphery
- cellular membrane
- secretory granule membrane
- tertiary granule membrane
- membrane rafts
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SIRPA gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of cytokine production involved in inflammatory response
- cell adhesion
- regulation of nitric oxide biosynthetic process
- regulation of interferon-gamma production
- positive regulation of T cell activation
- negative regulation of chemokine (C-C motif) ligand 5 production
- cellular response to hydrogen peroxide
- cell migration
- negative regulation of tumor necrosis factor production
- negative regulation of interferon-beta production
- monocyte extravasation
- negative regulation of inflammatory response
- regulation of tumor necrosis factor production
- negative regulation of JNK cascade
- negative regulation of nitric oxide biosynthetic process
- negative regulation of interleukin-6 production
- cellular response to lipopolysaccharide
- negative regulation of macrophage inflammatory protein 1 alpha production
- negative regulation of ERK1 and ERK2 cascade
- negative regulation of protein phosphorylation
- cellular response to interleukin-1
- regulation of gene expression
- regulation of interleukin-6 production
- regulation of interleukin-1 beta production
- heterotypic cell-cell adhesion
- cellular response to interferon-gamma
- positive regulation of phagocytosis
- cellular response to interleukin-12
- negative regulation of phagocytosis
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- membrane
- plasma membrane
- tertiary granule membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- protein phosphatase binding
- GTPase regulator activity
- protein binding involved in heterotypic cell-cell adhesion
- SH3 domain binding