CD47 Gene Summary [Human]
This gene encodes a membrane protein, which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. The encoded protein is also a receptor for the C-terminal cell binding domain of thrombospondin, and it may play a role in membrane transport and signal transduction. This gene has broad tissue distribution, and is reduced in expression on Rh erythrocytes. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2010]
Details
| Type | Protein Coding |
| Official Symbol | CD47 |
| Official Name | CD47 molecule [Source:HGNC Symbol;Acc:HGNC:1682] |
| Ensembl ID | ENSG00000196776 |
| Bio databases IDs | |
| Aliases | CD47 molecule, antigen identified by monoclonal antibody 1D8, antigenic surface determinant protein OA3, integrin associated protein, Rh-related antigen, leukocyte surface antigen CD47, CD47 glycoprotein |
| Synonyms | 9130415E20RIK, AA407862, B430305P08RIK, CD47 ANTIGEN, CD47 antigen (Rh-related antigen, integrin-associated signal transducer), CD47 molecule, CDw149, IAP, Itgp, LOC105374030, Locuslink 71587, MER6, OA3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CD47 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- signaling receptor activity
- immunoglobulin domain
- ectodomain
- cell adhesion molecule binding
- immunoglobulin variable region-like domain
- protein binding
- Ig-like V domain
- multiple membrane-spanning domain
- binding protein
- cytosolic tail domain
- transmembrane receptor
- CD47 transmembrane region
Pathways
Biological processes and signaling networks where the CD47 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- peripheral T-cell lymphoma
- cancer
- anemia
- multiple sclerosis
- neoplasia
- T-cell non-Hodgkin disease
- metastatic gastric adenocarcinoma
- psoriasis
- acute myeloid leukemia
- myelodysplastic syndrome
role in cell
- cellular infiltration
- quantity
- expression in
- apoptosis
- phosphorylation in
- cell spreading
- dissemination
- activation in
- function
- proliferation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- secondary granule fractions
- membrane fraction
- detergent resistant lipid raft fraction
- glutaminergic synapse
- presynaptic regions
- cell surface
- cellular membrane
- Nucleus
- tertiary granule membrane
- specific granule membrane
- myelin sheath
- microsomal membrane
- membrane rafts
- microvilli
- exosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CD47 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of cell-cell adhesion
- positive regulation of cell proliferation
- regulation of nitric oxide biosynthetic process
- regulation of Fc receptor mediated stimulatory signaling pathway
- regulation of interferon-gamma production
- positive regulation of monocyte extravasation
- integrin-mediated signaling pathway
- inflammatory response
- positive regulation of T cell activation
- angiogenesis
- apoptotic process
- cell migration
- positive regulation of inflammatory response
- regulation of tumor necrosis factor production
- positive regulation of stress fiber assembly
- cellular response to interleukin-1
- regulation of interleukin-6 production
- regulation of interleukin-10 production
- heterotypic cell-cell adhesion
- cellular response to interferon-gamma
- positive regulation of phagocytosis
- cellular response to interleukin-12
- regulation of interleukin-12 production
- negative regulation of phagocytosis
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- plasma membrane
- tertiary granule membrane
- cell surface
- specific granule membrane
Molecular Function
What the gene product does at the molecular level
- thrombospondin receptor activity
- protein binding
- protein binding involved in heterotypic cell-cell adhesion