SLC4A9 Gene Summary [Human]
The protein encoded by this gene is a membrane protein involved in anion exchange. Expression of this gene is mostly limited to the kidney. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]
Details
| Type | Protein Coding |
| Official Symbol | SLC4A9 |
| Official Name | solute carrier family 4 member 9 [Source:HGNC Symbol;Acc:HGNC:11035] |
| Ensembl ID | ENSG00000113073 |
| Bio databases IDs | |
| Aliases | solute carrier family 4 member 9 |
| Synonyms | AE 4, Anion exchanger 4, D630003B07, D630024F24RIK, SBC5, solute carrier family 4 member 9, solute carrier family 4, sodium bicarbonate cotransporter, member 9 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SLC4A9 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- sodium:bicarbonate symporter
- HCO3- transporter family
- Band 3 cytoplasmic domain
- sodium ion transporter
- antiporter
- anion exchange protein
- metal ion transporter
- chloride transporter
- inorganic anion exchanger
- bicarbonate transporter
- transporter
- anion transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- apical compartment
- cellular membrane
- basolateral cell surfaces
- basolateral membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SLC4A9 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of intracellular pH
- transmembrane transport
- saliva secretion
- sodium ion transmembrane transport
- bicarbonate transport
Cellular Component
Where in the cell the gene product is active
- apical part of cell
- basolateral plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- sodium:bicarbonate symporter activity