Slc4a9 Gene Summary [Rat]

Enables chloride:bicarbonate antiporter activity. Involved in monoatomic anion transport and sodium ion transmembrane transport. Located in basolateral plasma membrane. Orthologous to human SLC4A9 (solute carrier family 4 member 9). [provided by Alliance of Genome Resources, Jul 2025]

Details

Type
Protein Coding
Official Symbol
Slc4a9
Official Name
solute carrier family 4 member 9 [Source:RGD Symbol;Acc:628811]
Ensembl ID
ENSRNOG00000018525
Bio databases IDs NCBI: 266612 Ensembl: ENSRNOG00000018525
Aliases solute carrier family 4 member 9
Synonyms AE 4, Anion exchanger 4, D630003B07, D630024F24RIK, SBC5, solute carrier family 4 member 9, solute carrier family 4, sodium bicarbonate cotransporter, member 9
Species
Rat, Rattus norvegicus
OrthologiesHumanMouse

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Slc4a9 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • sodium:bicarbonate symporter
  • HCO3- transporter family
  • Band 3 cytoplasmic domain
  • sodium ion transporter
  • antiporter
  • anion exchange protein
  • metal ion transporter
  • chloride transporter
  • inorganic anion exchanger
  • bicarbonate transporter
  • transporter
  • anion transporter

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • renal clear cell adenocarcinoma
  • Alzheimer disease
  • renal clear cell cancer
regulated by
regulates
  • bicarbonate
  • anion
  • chloride
  • sodium chloride
  • Na+
role in cell
  • exiting in
  • chloride/bicarbonate exchange in

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Plasma Membrane
  • apical compartment
  • cellular membrane
  • basolateral cell surfaces
  • basolateral membrane

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the rat Slc4a9 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • regulation of intracellular pH
  • transmembrane transport
  • saliva secretion
  • sodium ion transmembrane transport
  • bicarbonate transport

Cellular Component

Where in the cell the gene product is active
  • apical part of cell
  • basolateral plasma membrane
  • plasma membrane

Molecular Function

What the gene product does at the molecular level
  • sodium:bicarbonate symporter activity

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.