TMIGD3 Gene Summary [Human]

This gene encodes a transmembrane and immunoglobulin domain-containing protein. Alternative splicing results in multiple transcript variants, one of which shares its 5' terminal exon with that of the overlapping adenosine A3 receptor gene (GeneID:140), thus resulting in a fusion product. [provided by RefSeq, Nov 2014]

Details

Type
Processed Transcript
Official Symbol
TMIGD3
Official Name
transmembrane and immunoglobulin domain containing 3 [Source:HGNC Symbol;Acc:HGNC:51375]
Ensembl ID
ENSG00000121933
Bio databases IDs NCBI: 57413 Ensembl: ENSG00000121933
Aliases transmembrane and immunoglobulin domain containing 3
Synonyms 1700001d09rik, 4930578J19Rik, AD026, LOC100365814, Tg(H2-K-CALR*)del52Shmd, transmembrane and immunoglobulin domain containing 3
Species
Human, Homo sapiens
OrthologiesRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TMIGD3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • immunoglobulin domain
  • Immunoglobulin V-set domain

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulates
  • NFkB (complex)
regulated by
  • lipopolysaccharide
  • dexamethasone
disease
  • primary pulmonary hypertension
  • COVID-19
  • stomatitis
  • fatigue
  • idiopathic scoliosis
role in cell
  • proliferation
  • migration

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Plasma Membrane
  • cellular membrane

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human TMIGD3 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • inflammatory response
  • signal transduction
  • negative regulation of NF-kappaB transcription factor activity
  • negative regulation of cell proliferation
  • regulation of heart contraction
  • response to wounding
  • activation of adenylate cyclase activity
  • negative regulation of cell migration

Cellular Component

Where in the cell the gene product is active
  • membrane
  • plasma membrane

Molecular Function

What the gene product does at the molecular level
  • transmembrane signaling receptor activity

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.