Adora3 Gene Summary [Rat]
Enables G protein-coupled adenosine receptor activity. Involved in G protein-coupled receptor signaling pathway; presynaptic modulation of chemical synaptic transmission; and regulation of norepinephrine secretion. Located in presynaptic membrane. Is active in Schaffer collateral - CA1 synapse. Orthologous to human ADORA3 (adenosine A3 receptor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Adora3 |
| Official Name | adenosine A3 receptor [Source:RGD Symbol;Acc:2051] |
| Ensembl ID | ENSRNOG00000015788 |
| Bio databases IDs | |
| Aliases | adenosine A3 receptor |
| Synonyms | 1700001d09rik, 4930578J19Rik, AD026, LOC100365814, Tg(H2-K-CALR*)del52Shmd, transmembrane and immunoglobulin domain containing 3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Adora3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- immunoglobulin domain
- Immunoglobulin V-set domain
Pathways
Biological processes and signaling networks where the Adora3 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- primary pulmonary hypertension
- COVID-19
- stomatitis
- fatigue
- idiopathic scoliosis
regulated by
- lipopolysaccharide
- dexamethasone
regulates
- NFkB (complex)
role in cell
- proliferation
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Adora3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- inflammatory response
- signal transduction
- negative regulation of NF-kappaB transcription factor activity
- negative regulation of cell proliferation
- regulation of heart contraction
- response to wounding
- activation of adenylate cyclase activity
- negative regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- transmembrane signaling receptor activity