NEURL2 Gene Summary [Human]
This gene encodes a protein that is involved in the regulation of myofibril organization. This protein is likely the adaptor component of the E3 ubiquitin ligase complex in striated muscle, and it regulates the ubiquitin-mediated degradation of beta-catenin during myogenesis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jun 2013]
Details
| Type | Protein Coding |
| Official Symbol | NEURL2 |
| Official Name | neuralized E3 ubiquitin protein ligase 2 [Source:HGNC Symbol;Acc:HGNC:16156] |
| Ensembl ID | ENSG00000124257 |
| Bio databases IDs | |
| Aliases | neuralized E3 ubiquitin protein ligase 2 |
| Synonyms | C20orf163, Neur2, neuralized E3 ubiquitin protein ligase 2, OZZ, OZZ-E3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NEURL2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SOCS box
- Neuralized
- SPRY domain
- SOCS
- protein binding
- domain in neuralized proteins
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
- cell-matrix adherens junctions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NEURL2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- intracellular signal transduction
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- cytosol