Neurl2 Gene Summary [Mouse]
Predicted to enable ubiquitin protein ligase activity. Acts upstream of or within sarcomere organization. Located in muscle tendon junction. Part of VCB complex. Is expressed in forebrain; gonad; metanephros; and submandibular gland. Orthologous to human NEURL2 (neuralized E3 ubiquitin protein ligase 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Neurl2 |
| Official Name | neuralized E3 ubiquitin protein ligase 2 [Source:MGI Symbol;Acc:MGI:3043305] |
| Ensembl ID | ENSMUSG00000039873 |
| Bio databases IDs | |
| Aliases | neuralized E3 ubiquitin protein ligase 2 |
| Synonyms | C20orf163, Neur2, neuralized E3 ubiquitin protein ligase 2, OZZ, OZZ-E3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Neurl2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SOCS box
- Neuralized
- SPRY domain
- SOCS
- protein binding
- domain in neuralized proteins
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
- cell-matrix adherens junctions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Neurl2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- intracellular signal transduction
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- cytosol