ENO1 Gene Summary [Human]
This gene encodes alpha-enolase, one of three enolase isoenzymes found in mammals. Each isoenzyme is a homodimer composed of 2 alpha, 2 gamma, or 2 beta subunits, and functions as a glycolytic enzyme. Alpha-enolase in addition, functions as a structural lens protein (tau-crystallin) in the monomeric form. Alternative splicing of this gene results in a shorter isoform that has been shown to bind to the c-myc promoter and function as a tumor suppressor. Several pseudogenes have been identified, including one on the long arm of chromosome 1. Alpha-enolase has also been identified as an autoantigen in Hashimoto encephalopathy. [provided by RefSeq, Jan 2011]
Details
| Type | Protein Coding |
| Official Symbol | ENO1 |
| Official Name | enolase 1 [Source:HGNC Symbol;Acc:HGNC:3350] |
| Ensembl ID | ENSG00000074800 |
| Bio databases IDs | |
| Aliases | enolase 1, alpha-enolase |
| Synonyms | ENO1-IT1, ENO1L1, ENOA, ENOLASE, ENOLASE 1, Enolase 1 alpha, enolase 1, alpha non-neuron, Enolase 1 α, enolase 1, α non-neuron, Enolase α, HEL-S-17, LOC100503183, MBP-1, MPB1, NNE, Phosphopyruvate hydratase, PPH, α enolase |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ENO1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- nucleic acid binding
- transcription co-repressor
- heat shock protein binding
- enzyme binding
- transcription factor binding
- phosphopyruvate hydratase
- enzyme
- protein binding
- Enolase, N-terminal domain
- sequence-specific DNA binding
- identical protein binding
- RNA binding
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- enolase_like
- Enolase, C-terminal TIM barrel domain
- binding protein
- double-stranded DNA binding
- TIM-like beta/alpha barrel domains
- protein homodimerization
Pathways
Biological processes and signaling networks where the ENO1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- neoplasia
- papillary thyroid cancer
- asthma
- rheumatoid arthritis
- colorectal cancer
- obesity
- organismal death
- papillary thyroid carcinoma
- anaplastic thyroid carcinoma
role in cell
- apoptosis
- expression in
- activation in
- formation in
- proliferation
- production in
- differentiation
- cell death
- growth
- phosphorylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- myelin enriched fraction
- membrane fraction
- detergent resistant lipid raft fraction
- Cytoplasm
- cell surface
- cell periphery
- cellular membrane
- cell cortex
- Nucleus
- lipid droplets
- cytosol
- synaptic membrane
- outer nuclear membrane
- growth cone
- Z line
- membrane rafts
- exosomes
- phagosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ENO1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- gluconeogenesis
- negative regulation of transcription, DNA-dependent
- negative regulation of cell growth
- positive regulation of ATP biosynthetic process
- glycolysis
- positive regulation of plasminogen activation
- response to virus
- positive regulation of muscle contraction
Cellular Component
Where in the cell the gene product is active
- nuclear outer membrane
- phosphopyruvate hydratase complex
- plasma membrane
- cell surface
- nucleus
- extracellular space
- extracellular vesicular exosome
- cytoplasm
- cell cortex
- membrane
- cytosol
- M band
Molecular Function
What the gene product does at the molecular level
- transcription corepressor binding
- magnesium ion binding
- phosphopyruvate hydratase activity
- protein homodimerization activity
- RNA binding
- protein binding
- transcription corepressor activity
- cadherin binding
- GTPase binding
- RNA polymerase II regulatory region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription