FUT5 Gene Summary [Human]
Enables 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity and 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity. Involved in ceramide metabolic process and oligosaccharide metabolic process. Predicted to be located in Golgi membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | FUT5 |
| Official Name | fucosyltransferase 5 [Source:HGNC Symbol;Acc:HGNC:4016] |
| Ensembl ID | ENSG00000130383 |
| Bio databases IDs | |
| Aliases | fucosyltransferase 5, alpha (1,3) fucosyltransferase |
| Synonyms | fucosyltransferase 5, FUC-TV |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human FUT5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- 3-alpha-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase
- alpha(1,3)-fucosyltransferase
- Fucosyltransferase, N-terminal
- fucosyltransferase
- enzyme
- Glycosyltransferase family 10 (fucosyltransferase) C-term
- galactoside 3-fucosyltransferase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Golgi Apparatus
- Golgi membrane
- trans Golgi cisternae
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human FUT5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- carbohydrate metabolic process
- protein O-linked glycosylation
- fucosylation
- protein glycosylation
- protein N-linked glycosylation
- oligosaccharide biosynthetic process
- oligosaccharide metabolic process
- ceramide metabolic process
- L-fucose catabolic process
Cellular Component
Where in the cell the gene product is active
- Golgi cisterna membrane
- Golgi apparatus
- Golgi membrane
Molecular Function
What the gene product does at the molecular level
- 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity
- 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity
- fucosyltransferase activity
- alpha-(1->3)-fucosyltransferase activity