PLXNA3 Gene Summary [Human]
This gene encodes a member of the plexin class of proteins. The encoded protein is a class 3 semaphorin receptor, and may be involved in cytoskeletal remodeling and as well as apoptosis. Studies of a similar gene in zebrafish suggest that it is important for axon pathfinding in the developing nervous system. This gene may be associated with tumor progression. [provided by RefSeq, Aug 2013]
Details
| Type | Protein Coding |
| Official Symbol | PLXNA3 |
| Official Name | plexin A3 [Source:HGNC Symbol;Acc:HGNC:9101] |
| Ensembl ID | ENSG00000130827 |
| Bio databases IDs | |
| Aliases | plexin A3 |
| Synonyms | 6.3, HSSEXGENE, mKIAA4078, PlexA3, plexin A3, Plxa3, PLXN3, PLXN4, SEX, XAP-6 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PLXNA3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Plexin repeat
- IPT
- Plexin cytoplasmic RasGAP domain
- protein binding
- TIG domain
- Ras GTPase Activating Domain
- semaphorin domain
- Plexin cytoplasmic RhoGTPase-binding domain
- TIG domain found in plexin
- IPT/TIG domain
- semaphorin receptor
- Sema domain
- transmembrane receptor
- The Sema domain, a protein interacting module, of semaphorins and plexins
Pathways
Biological processes and signaling networks where the PLXNA3 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- pancreatic ductal adenocarcinoma
- pancreatic epithelial cancer
- ductal pancreatic cancer
- osteoporosis
- latent tuberculosis
- Vogt-Koyanagi-Harada disease
regulates
role in cell
- apoptosis
- cell death
- number
- development
- guidance
- stimulation
- organization
- outgrowth
- outgrowth in
- sum total
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- growth cone
- perikaryon
- axons
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PLXNA3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cell shape
- gonadotrophin-releasing hormone neuronal migration to the hypothalamus
- negative chemotaxis
- trigeminal nerve structural organization
- negative regulation of cell adhesion
- olfactory nerve formation
- axon guidance
- hippocampus development
- negative regulation of axon extension involved in axon guidance
- facial nerve structural organization
- pyramidal neuron development
- branchiomotor neuron axon guidance
- axon extension involved in axon guidance
- positive regulation of axonogenesis
- positive regulation of cytoskeleton organization
- regulation of GTPase activity
- regulation of cell migration
- semaphorin-plexin signaling pathway
Cellular Component
Where in the cell the gene product is active
- semaphorin receptor complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- semaphorin receptor activity