icon_0328_cc_gen_hmr_bacteria-s

Axonal Guidance Signaling

Neuronal connections are formed by the extension of axons, which migrate to reach their synaptic targets. The axonal growth cone, located at the axon leading edge, contains receptors that sense attractive and repulsive guidance cues, which help navigate the axon to its final destination....

Axonal Guidance Signaling

Pathway Summary

Neuronal connections are formed by the extension of axons, which migrate to reach their synaptic targets. The axonal growth cone, located at the axon leading edge, contains receptors that sense attractive and repulsive guidance cues, which help navigate the axon to its final destination.Four major families of attractive and repulsive guidance cues and receptors have been identified: 1) Netrins and DCC and UNC-5 receptors, 2) Slits and Robo receptors, 3) Semaphorins and plexin and neurophilin receptors and, 4) Ephrins and Eph receptors. In addition, more recently, Shh, BMP, and Wnt been implicated in growth cone guidance.Netrins, Slits, and some Semaphorins are secreted proteins that associate with cells or the extracellular matrix, whereas Ephrins and other Semaphorins are anchored to the cell surface. Many guidance cues are bifunctional, producing an attractive response for some growth cones, while acting as repulsive guidance cue in other contexts. Guidance receptors signal as multimeric complexes. Some receptors are relatively specific for a particular function: for example, UNC-5 is only known to act in netrin repulsion. Other receptors are more promiscuous, interacting with multiple partners in a variety of signaling events. Attractive cues promote actin polymerization and axon extension, whereas repulsive cues decrease actin polymerization, resulting in growth cone collapse and axon retraction. The Rho family of GTPases, which regulates the formation of a wide range of cytoskeletal structures, is strongly implicated in axonal guidance.

Axonal Guidance Signaling Genes list

Explore Genes related to Axonal Guidance Signaling

Products related to Axonal Guidance Signaling

Explore products related to Axonal Guidance Signaling
GeneGlobe ID: UPHS-031Z | Cat. No.: 249955 | QuantiNova LNA Probe PCR Focus Panels
QuantiNova LNA Probe PCR Focus Panel Human Neurotrophins & Receptors
QuantiNova LNA Probe PCR Focus Panel
Product Specification
Copy Details
GeneGlobe ID: SBHS-060Z | Cat. No.: 249950 | QuantiNova LNA PCR Focus Panels
QuantiNova LNA PCR Focus Panel Human Neurotransmitter Receptors
QuantiNova LNA PCR Focus Panel
Product Specification
Copy Details
GeneGlobe ID: UPHS-060Z | Cat. No.: 249955 | QuantiNova LNA Probe PCR Focus Panels
QuantiNova LNA Probe PCR Focus Panel Human Neurotransmitter Receptors
QuantiNova LNA Probe PCR Focus Panel
Product Specification
Copy Details
GeneGlobe ID: SBHS-031Z | Cat. No.: 249950 | QuantiNova LNA PCR Focus Panels
QuantiNova LNA PCR Focus Panel Human Neurotrophins & Receptors
QuantiNova LNA PCR Focus Panel
Product Specification
Copy Details
GeneGlobe ID: PAHS-060Z | Cat. No.: 330231 | RT2 Profiler PCR Arrays
RT² Profiler™ PCR Array Human Neurotransmitter Receptors
RT2 Profiler PCR Array
Product Specification
Copy Details
GeneGlobe ID: PAHS-031Z | Cat. No.: 330231 | RT2 Profiler PCR Arrays
RT² Profiler™ PCR Array Human Neurotrophins & Receptors
RT2 Profiler PCR Array
Product Specification
Copy Details

Didn't find what you're looking for?

Discover other products relevant to this gene list with our Panel Finder. Check it out.