PSMD14 Gene Summary [Human]
This gene encodes a component of the 26S proteasome. The 26S proteasome is a large multiprotein complex that catalyzes the degradation of ubiquitinated intracellular proteins. The encoded protein is a component of the 19S regulatory cap complex of the 26S proteasome and mediates substrate deubiquitination. A pseudogene of this gene is also located on the long arm of chromosome 2. [provided by RefSeq, Feb 2012]
Details
| Type | Protein Coding |
| Official Symbol | PSMD14 |
| Official Name | proteasome 26S subunit, non-ATPase 14 [Source:HGNC Symbol;Acc:HGNC:16889] |
| Ensembl ID | ENSG00000115233 |
| Bio databases IDs | |
| Aliases | proteasome 26S subunit, non-ATPase 14 |
| Synonyms | 2610312C03Rik, 26S Proteasome Associated Pad1 Homolog, 3200001M20Rik, LOC311078, PAD1, POH1, proteasome 26S subunit, non-ATPase 14, proteasome (prosome, macropain) 26S subunit, non-ATPase, 14, rpm11, RPN11, Tbr1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PSMD14 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- metallopeptidase
- endopeptidase
- Mpr1p, Pad1p N-terminal (MPN) domains
- binding protein
- peptidase
- protein binding
- enzyme regulator activity
- Maintenance of mitochondrial structure and function
- protease activator
- ubiquitin-like-specific protease
Pathways
Biological processes and signaling networks where the PSMD14 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- non-insulin-dependent diabetes mellitus
- Crohn disease
- tumorigenesis
- head and neck squamous cell carcinoma
- head and neck squamous cell cancer
- organismal death
- glycogen storage disease type II
- colon cancer
- insomnia
role in cell
- expression in
- phosphorylation in
- proliferation
- cell death
- survival
- degradation in
- growth
- colony formation
- tamoxifen sensitivity
- cisplatin sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- secretory granule lumen
- ficolin-1-rich granule lumen
- Extracellular Space
- Nucleus
- cytosol
- nucleoplasm
- nuclear rim
- cytoplasmic droplets
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PSMD14 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein deubiquitination
- response to ethanol
- proteasomal ubiquitin-dependent protein catabolic process
- regulation of proteasomal protein catabolic process
- double-strand break repair via homologous recombination
- double-strand break repair via nonhomologous end joining
- protein K63-linked deubiquitination
- ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
- cytosolic proteasome complex
- proteasome accessory complex
- proteasome complex
- secretory granule lumen
- proteasome regulatory particle, lid subcomplex
- extracellular region
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- endopeptidase activator activity
- protein binding
- proteasome binding
- metal ion binding
- metallopeptidase activity