SLCO2B1 Gene Summary [Human]
This locus encodes a member of the organic anion-transporting polypeptide family of membrane proteins. The protein encoded by this locus may function in regulation of placental uptake of sulfated steroids. Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2010]
Details
| Type | Processed Transcript |
| Official Symbol | SLCO2B1 |
| Official Name | solute carrier organic anion transporter family member 2B1 [Source:HGNC Symbol;Acc:HGNC:10962] |
| Ensembl ID | ENSG00000137491 |
| Bio databases IDs | |
| Aliases | solute carrier organic anion transporter family member 2B1 |
| Synonyms | moat1, OATP2B1, OATP-B, SLC21A9, solute carrier organic anion transporter family member 2B1, solute carrier organic anion transporter family, member 2b1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SLCO2B1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Organic Anion Transporter Polypeptide (OATP) family
- sodium-independent organic anion transporter
- Major Facilitator Superfamily
- bile acid transporter
- organic anion transporter
- KAZAL_FS
- prostaglandin transporter
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- asthma
- peripheral arterial disease
- ischemic cardiomyopathy
- dilated cardiomyopathy
regulates
- estrone sulfate
- aspirin
- fexofenadine
- pravastatin
- xenobiotic
- bilirubin
- montelukast
- zinc mesoporphyrin
- hemin
- heavy metal
role in cell
- proliferation
- survival
- bafilomycin A1 resistance
- accumulation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- apical membrane
- basolateral membrane
- basal membrane
- sinusoidal membrane
- brush border
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SLCO2B1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ion transport
- transmembrane transport
- sodium-independent organic anion transport
- xenobiotic metabolic process
- heme catabolic process
- organic anion transport
- prostaglandin transport
- bile acid and bile salt transport
Cellular Component
Where in the cell the gene product is active
- basal plasma membrane
- basolateral plasma membrane
- plasma membrane
- apical plasma membrane
Molecular Function
What the gene product does at the molecular level
- bile acid transmembrane transporter activity
- transmembrane transporter activity
- prostaglandin transmembrane transporter activity
- organic anion transmembrane transporter activity
- sodium-independent organic anion transmembrane transporter activity