PARP6
PARP6 Gene Summary
Enables protein ADP-ribosylase activity. Involved in protein auto-ADP-ribosylation and protein mono-ADP-ribosylation. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | PARP6 |
| Official Name | poly(ADP-ribose) polymerase family member 6 [Source:HGNC Symbol;Acc:HGNC:26921] |
| Ensembl ID | ENSG00000137817 |
| Bio databases IDs | |
| Aliases | poly(ADP-ribose) polymerase family member 6 |
| Synonyms | 1700119G14Rik,2310028P13Rik,3110038K10Rik,ARTD17,C030013N01Rik,PARP-6-B1,PARP-6-C,pART17,poly (ADP-ribose) polymerase family, member 6,poly(ADP-ribose) polymerase family member 6,RGD1310937 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- pentosyltransferase
- enzyme
- ADP_ribosyl
Pathways
Biological processes and signaling networks where the PARP6 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- RIGI
- MDM2
- XRCC6
disease
regulated by
regulates
- IFNB1
- CHEK1
role in cell
- expression in
- morphogenesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the PARP6 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- endoplasmic reticulum unfolded protein response
- protein auto-ADP-ribosylation
- positive regulation of dendrite morphogenesis
CELLULAR COMPONENT
Where in the cell the gene product is active
- nuclear envelope
- endoplasmic reticulum tubular network
MOLECULAR FUNCTION
What the gene product does at the molecular level
- nucleotidyltransferase activity
- protein serine/threonine kinase activator activity
- kinase binding
- NAD+ ADP-ribosyltransferase activity