SLC38A4 Gene Summary [Human]
SLC38A4 is found predominantly in liver and transports both cationic and neutral amino acids. The transport of cationic amino acids by SLC38A4 is Na(+) and pH independent, while the transport of neutral amino acids is Na(+) and pH dependent (Hatanaka et al., 2001 [PubMed 11342143]).[supplied by OMIM, Mar 2008]
Details
| Type | Protein Coding |
| Official Symbol | SLC38A4 |
| Official Name | solute carrier family 38 member 4 [Source:HGNC Symbol;Acc:HGNC:14679] |
| Ensembl ID | ENSG00000139209 |
| Bio databases IDs | |
| Aliases | solute carrier family 38 member 4 |
| Synonyms | 1110012E16Rik, 1700012A18Rik, ATA3, mATA3, mNAT3, NAT3, PAAT, SNAT4, solute carrier family 38 member 4, solute carrier family 38, member 4 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SLC38A4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- neutral amino acid:sodium symporter
- organic cation transporter
- alanine:sodium symporter
- L-amino acid transporter
- sodium:amino acid transporter
- protein binding
- basic amino acid transporter
- Solute carrier families 5 and 6-like; solute binding domain
- amino acid transporter
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- microvilli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SLC38A4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neutral amino acid transport
- sodium ion transmembrane transport
- amino acid transport
- amino acid transmembrane transport
Cellular Component
Where in the cell the gene product is active
- microvillus membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- L-amino acid transmembrane transporter activity
- protein binding
- neutral amino acid:sodium symporter activity
- sodium:amino acid symporter activity
- amino acid transmembrane transporter activity
- alanine:sodium symporter activity