UBE2Q2 Gene Summary [Human]

Enables ubiquitin-protein transferase activity. Involved in protein K48-linked ubiquitination. Predicted to be located in cytosol. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

Details

Type
Protein Coding
Official Symbol
UBE2Q2
Official Name
ubiquitin conjugating enzyme E2 Q2 [Source:HGNC Symbol;Acc:HGNC:19248]
Ensembl ID
ENSG00000140367
Bio databases IDs NCBI: 92912 Ensembl: ENSG00000140367
Aliases ubiquitin conjugating enzyme E2 Q2
Synonyms 3010021M21Rik, RGD1307680, ubiquitin conjugating enzyme E2 Q2, ubiquitin-conjugating enzyme E2Q family member 2
Species
Human, Homo sapiens
OrthologiesMouseRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human UBE2Q2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • ubiquitin conjugating enzyme
  • ubiquitin-protein transferase activity
  • RWD domain
  • UBCc_UEV
  • enzyme
  • protein binding

Pathways

Biological processes and signaling networks where the UBE2Q2 gene in human plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • gout
  • chronic kidney disease
regulated by
  • GABA

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • cytosol

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human UBE2Q2 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • protein K48-linked ubiquitination

Cellular Component

Where in the cell the gene product is active
  • nucleus
  • cytosol

Molecular Function

What the gene product does at the molecular level
  • ATP binding
  • ubiquitin-protein ligase activity
  • protein binding

Gene-Specific Assays for Results You Can Trust

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