UBC Gene Summary [Human]

This gene represents a ubiquitin gene, ubiquitin C. The encoded protein is a polyubiquitin precursor. Conjugation of ubiquitin monomers or polymers can lead to various effects within a cell, depending on the residues to which ubiquitin is conjugated. Ubiquitination has been associated with protein degradation, DNA repair, cell cycle regulation, kinase modification, endocytosis, and regulation of other cell signaling pathways. [provided by RefSeq, Aug 2010]

Details

Type
Protein Coding
Official Symbol
UBC
Official Name
ubiquitin C [Source:HGNC Symbol;Acc:HGNC:12468]
Ensembl ID
ENSG00000150991
Bio databases IDs NCBI: 7316 Ensembl: ENSG00000150991
Aliases ubiquitin C, polyubiquitin-C
Synonyms 2700054O04Rik, HMG20, Polyubiquitin, Rps27a, TI-225, Uba52, Ubb, UBIQUITIN C
Species
Human, Homo sapiens
OrthologiesMouseRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human UBC often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • Ubiquitin family
  • Ubl1_cv_Nsp3_N-like
  • Ubiquitin homologues
  • enzyme
  • protein binding

Pathways

Biological processes and signaling networks where the UBC gene in human plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • organismal death
  • epileptic seizure
regulated by
regulates
role in cell
  • proliferation
  • degradation in
  • growth
  • replicative senescence
  • cell cycle progression
  • destabilization in

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • endocytic vesicle membrane
  • Plasma Membrane
  • cytosol
  • endoplasmic reticulum membrane
  • mitochondrial outer membrane
  • endosomal membrane
  • nucleoplasm
  • nucleoli

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human UBC gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • modification-dependent protein catabolic process
  • protein ubiquitination

Cellular Component

Where in the cell the gene product is active
  • mitochondrial outer membrane
  • plasma membrane
  • nucleoplasm
  • endoplasmic reticulum membrane
  • nucleus
  • extracellular space
  • extracellular vesicular exosome
  • cytoplasm
  • vesicle
  • cytosol
  • endosome membrane
  • endocytic vesicle membrane

Molecular Function

What the gene product does at the molecular level
  • ubiquitin protein ligase binding
  • RNA binding
  • protein binding
  • protein tag

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.