DPT Gene Summary [Human]
Dermatopontin is an extracellular matrix protein with possible functions in cell-matrix interactions and matrix assembly. The protein is found in various tissues and many of its tyrosine residues are sulphated. Dermatopontin is postulated to modify the behavior of TGF-beta through interaction with decorin. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | DPT |
| Official Name | dermatopontin [Source:HGNC Symbol;Acc:HGNC:3011] |
| Ensembl ID | ENSG00000143196 |
| Bio databases IDs | |
| Aliases | dermatopontin |
| Synonyms | 1810032B19Rik, 5033416F05Rik, Dermatopontin, EQ-1, TRAMP |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DPT often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Dermatopontin
- extracellular matrix structural constituent
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- adenoma formation
- epithelial cancer
- prostate cancer
- primary pulmonary hypertension
- hepatocellular carcinoma
- liver cancer
- colorectal adenoma
- colorectal adenoma formation
- colorectal cancer
- phobic anxiety disorder
regulates
role in cell
- proliferation
- growth
- accumulation in
- phosphorylation in
- migration
- invasion by
- colony formation by
- organization
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- extracellular matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DPT gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of cell proliferation
- cell adhesion
- collagen fibril organization
Cellular Component
Where in the cell the gene product is active
- extracellular space
Molecular Function
What the gene product does at the molecular level
- protein binding
- extracellular matrix structural constituent