IL10RA Gene Summary [Human]
The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene. [provided by RefSeq, Jan 2009]
Details
| Type | Retained Intron |
| Official Symbol | IL10RA |
| Official Name | interleukin 10 receptor subunit alpha [Source:HGNC Symbol;Acc:HGNC:5964] |
| Ensembl ID | ENSG00000110324 |
| Bio databases IDs | |
| Aliases | interleukin 10 receptor subunit alpha |
| Synonyms | CD210, CD210a, CDw210, CDW210A, HIL-10R, IL10R, IL-10R1, IL-10 R alpha, IL-10 R α, interleukin 10 receptor, alpha, interleukin 10 receptor subunit alpha, interleukin 10 receptor subunit α, interleukin 10 receptor, α, mIL-10R |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human IL10RA often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- signaling receptor activity
- cytoplasmic domain
- interleukin-10 receptor
- interleukin-10 binding
- intracellular domain
- protein binding
- JAK1bd_box_IFNLR1-like
- Interferon-alpha/beta receptor, fibronectin type III
- Tissue factor
- transmembrane receptor
Pathways
Biological processes and signaling networks where the IL10RA gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colitis
- dextran sodium sulfate-induced colitis
- obesity
- insulin-dependent diabetes mellitus
- organismal death
- Crohn disease
- autosomal recessive inflammatory bowel disease type 28
- chronic fatigue syndrome
- colorectal cancer
- rheumatoid arthritis
role in cell
- expression in
- differentiation
- proliferation
- accumulation
- activation in
- killing
- production in
- migration
- growth
- phosphorylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cilia
- cell surface
- intracellular space
- cellular membrane
- cytosol
- apical membrane
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human IL10RA gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ubiquitin-dependent endocytosis
- regulation of synapse organization
- intestinal epithelial structure maintenance
- negative regulation of inflammatory response
- negative regulation of autophagy
- cytokine-mediated signaling pathway
- response to lipopolysaccharide
- positive regulation of JAK-STAT cascade
Cellular Component
Where in the cell the gene product is active
- cytosol
- apical plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- interleukin-10 receptor activity
- protein binding
- interleukin-10 binding
- signaling receptor activity