REG3G Gene Summary [Human]
This gene encodes a member of the regenerating islet-derived genes (REG)3 protein family. These proteins are secreted, C-type lectins with a carbohydrate recognition domain and N-terminal signal peptide. The protein encoded by this gene is an antimicrobial lectin with activity against Gram-positive bacteria. Alternative splicing results in multiple transcript variants encoding multiple isoforms. [provided by RefSeq, Nov 2014]
Details
| Type | Protein Coding |
| Official Symbol | REG3G |
| Official Name | regenerating family member 3 gamma [Source:HGNC Symbol;Acc:HGNC:29595] |
| Ensembl ID | ENSG00000143954 |
| Bio databases IDs | |
| Aliases | regenerating family member 3 gamma |
| Synonyms | LPPM429, PAP-1B, PAP IB, regenerating family member 3 gamma, regenerating family member 3 γ, REG-III, UNQ429 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human REG3G often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- C-type lectin (CTL)/C-type lectin-like (CTLD) domain
- Lectin C-type domain
- peptidoglycan binding
- carbohydrate binding
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human REG3G gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of keratinocyte proliferation
- negative regulation of keratinocyte differentiation
- MyD88-dependent toll-like receptor signaling pathway
- positive regulation of wound healing
- positive regulation of cell proliferation
- acute-phase response
- response to peptide hormone stimulus
- defense response to Gram-positive bacterium
Cellular Component
Where in the cell the gene product is active
- extracellular space
- cytoplasm
- extracellular region
Molecular Function
What the gene product does at the molecular level
- oligosaccharide binding
- peptidoglycan binding
- metal ion binding
- signaling receptor activity