IL22 Gene Summary [Human]
This gene is a member of the IL10 family of cytokines that mediate cellular inflammatory responses. The encoded protein functions in antimicrobial defense at mucosal surfaces and in tissue repair. This protein also has pro-inflammatory properties and plays a role in in the pathogenesis of several intestinal diseases. The encoded protein is a crucial cytokine that regulates host immunity in infectious diseases, including COVID-19 (disease caused by SARS-CoV-2). [provided by RefSeq, Dec 2021]
Details
| Type | Protein Coding |
| Official Symbol | IL22 |
| Official Name | interleukin 22 [Source:HGNC Symbol;Acc:HGNC:14900] |
| Ensembl ID | ENSG00000127318 |
| Bio databases IDs | |
| Aliases | interleukin 22, IL-10-related T-cell-derived inducible factor |
| Synonyms | If2b1, IL-D110, IL-TIF, interleukin 22, RGD1561292, TIFa, TIFIL-23, zcyto18 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human IL22 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- cytokine
- Interleukin 10
Pathways
Biological processes and signaling networks where the IL22 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- kidney disease
- weight loss
- edema
- cancer
- hepatic steatosis
- neoplasia
- insulin-dependent diabetes mellitus
- epithelial neoplasia
- experimental autoimmune encephalomyelitis
- fibrosis
role in cell
- expression in
- migration
- differentiation
- apoptosis
- phosphorylation in
- proliferation
- production in
- chemotaxis
- activation in
- degradation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human IL22 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- inflammatory response
- signal transduction
- negative regulation of inflammatory response
- response to glucocorticoid stimulus
- acute-phase response
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular region
Molecular Function
What the gene product does at the molecular level
- interleukin-22 receptor binding
- protein binding
- cytokine activity