GPHA2 Gene Summary [Human]
GPHA2 is a cystine knot-forming polypeptide and a subunit of the dimeric glycoprotein hormone family (Hsu et al., 2002 [PubMed 12089349]).[supplied by OMIM, Mar 2008]
Details
| Type | Protein Coding |
| Official Symbol | GPHA2 |
| Official Name | glycoprotein hormone subunit alpha 2 [Source:HGNC Symbol;Acc:HGNC:18054] |
| Ensembl ID | ENSG00000149735 |
| Bio databases IDs | |
| Aliases | glycoprotein hormone subunit alpha 2, glycoprotein alpha 2, cysteine knot protein, thyrostimulin subunit alpha |
| Synonyms | A2, glycoprotein hormone alpha 2, glycoprotein hormone subunit alpha 2, glycoprotein hormone subunit α 2, glycoprotein hormone α 2, GPA2, Thyrostimulin alpha-2 subunit, Thyrostimulin α-2 subunit, ZSIG51 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GPHA2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein-coupled receptor binding
- protein binding
- receptor binding
- protein heterodimerization
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GPHA2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell surface receptor signaling pathway
- adenylate cyclase-activating G-protein coupled receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein heterodimerization activity
- thyrotropin-releasing hormone receptor binding
- hormone activity