CPB1
CPB1 Gene Summary
Three different procarboxypeptidases A and two different procarboxypeptidases B have been isolated. The B1 and B2 forms differ from each other mainly in isoelectric point. Carboxypeptidase B1 is a highly tissue-specific protein and is a useful serum marker for acute pancreatitis and dysfunction of pancreatic transplants. It is not elevated in pancreatic carcinoma. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | CPB1 |
| Official Name | carboxypeptidase B1 [Source:HGNC Symbol;Acc:HGNC:2299] |
| Ensembl ID | ENSG00000153002 |
| Bio databases IDs | |
| Aliases | carboxypeptidase B1, pancreatic carboxypeptidase B, tissue carboxypeptidase B, protaminase |
| Synonyms | 0910001A18Rik,1810063F02Rik,2210008M23Rik,carboxypeptidase B1,CPB,PASP,PCPB |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc carboxypeptidase
- carboxypeptidase
- Zn_pept domain
- peptidase
- carboxypeptidase B
- protein binding
- M14 family of metallocarboxypeptidases and related proteins
- Carboxypeptidase activation peptide
Pathways
Biological processes and signaling networks where the CPB1 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- SIRT1
disease
- pancreatic cancer
- migraines
regulated by
- AHR
- NEUROG3
- HFE
regulates
- Casp4
role in cell
- expression in
- cell death
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the CPB1 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- proteolysis
CELLULAR COMPONENT
Where in the cell the gene product is active
- extracellular space
- cytoplasmic vesicle
MOLECULAR FUNCTION
What the gene product does at the molecular level
- carboxypeptidase activity
- zinc ion binding
- protein binding
- metallocarboxypeptidase activity