AHR
AHR Gene Summary
The protein encoded by this gene is a ligand-activated helix-loop-helix transcription factor involved in the regulation of biological responses to planar aromatic hydrocarbons. This receptor has been shown to regulate xenobiotic-metabolizing enzymes such as cytochrome P450. Before ligand binding, the encoded protein is sequestered in the cytoplasm; upon ligand binding, this protein moves to the nucleus and stimulates transcription of target genes. [provided by RefSeq, Sep 2015]
Details
| Type | Processed Transcript |
| Official Symbol | AHR |
| Official Name | aryl hydrocarbon receptor [Source:HGNC Symbol;Acc:HGNC:348] |
| Ensembl ID | ENSG00000106546 |
| Bio databases IDs | |
| Aliases | aryl hydrocarbon receptor |
| Synonyms | Ah,Ahh,Ahre,AH receptor,aryl-hydrocarbon receptor,bHLHe76,DIOXIN receptor,FVH3,In,RP85 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Pst domain
- heat shock protein binding
- transcription activation domain
- transcription factor binding
- LXCXE binding site
- glutamine-rich domain
- identical protein binding
- TATA-binding protein binding
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- aryl hydrocarbon receptor binding
- reduced flavin or flavoprotein:oxygen oxidoreductase
- ligand-binding domain
- ligand-dependent nuclear receptor
- chaperone binding
- helix-loop-helix domain
- dioxin response element binding site
- Helix-loop-helix DNA-binding domain
- basic domain
- nuclear export signal
- DNA binding domain
- nucleic acid binding
- PAS
- basic Helix Loop Helix (bHLH) domain superfamily
- alpha helix
- nuclear localization sequence
- protein binding
- basic helix loop helix/Per Arnt Sim domain
- sequence-specific DNA binding
- acidic domain
- PAS fold
- DNA binding
- binding protein
- STP box
- PAS domain
- LHCAE domain
- double-stranded DNA binding
- protein homodimerization
- helix loop helix domain
- Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)
- CAD domain
- transcription factor activity
- protein heterodimerization
- toxin binding
Pathways
Biological processes and signaling networks where the AHR gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- ARNT
- SIM1
- SIM2
- E2F1
- AIP
- HSP90AA1
- TP53
- p23
- TGF beta
- CTNNB1
disease
- neoplasia
- cancer
- lung cancer
- epithelial cancer
- epithelial neoplasia
- dextran sodium sulfate-induced colitis
- myelin oligodendrocyte glycoprotein induced experimental autoimmune encephalomyelitis
- hepatic fibrosis
- fibrosis
- cleft palate syndrome
regulated by
- alpha-naphthoflavone
- Ca2+
- Immunoglobulin
- MYC
- activin (family)
- Hepatitis C virus JFH-1
- tetrachlorodibenzodioxin
- FSH
- bisphenol A
- Bt 549 cells
regulates
- cyclic AMP
- TNF
- IFNG
- CD40LG
- TGFB1
- CXCL8
- testosterone
- APP
- reactive oxygen species
- lipid
role in cell
- proliferation
- growth
- expression in
- accumulation
- synthesis in
- apoptosis
- production in
- mitogenesis
- inhibition
- quantity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- cell periphery
- cytosol
- nucleoplasm
- chromatin
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the AHR gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- negative regulation of inflammatory response
- regulation of transcription, DNA-dependent
- response to xenobiotic stimulus
- positive regulation of transcription from RNA polymerase II promoter
- response to toxin
- regulation of transcription from RNA polymerase II promoter
- regulation of B cell proliferation
- negative regulation of T cell mediated immune response to tumor cell
- circadian regulation of gene expression
- blood vessel development
- negative regulation of transcription, DNA-dependent
- positive regulation of transcription, DNA-dependent
- xenobiotic metabolic process
- apoptotic process
- cellular response to cAMP
- regulation of gene expression
- regulation of adaptive immune response
- cellular response to molecule of bacterial origin
- cAMP-mediated signaling
- intracellular receptor mediated signaling pathway
CELLULAR COMPONENT
Where in the cell the gene product is active
- transcription factor complex
- nucleus
- cytoplasm
- cytosol
- nuclear aryl hydrocarbon receptor complex
- macromolecular complex
- cytosolic aryl hydrocarbon receptor complex
- aryl hydrocarbon receptor complex
- chromatin
- nucleoplasm
MOLECULAR FUNCTION
What the gene product does at the molecular level
- protein homodimerization activity
- transcription regulatory region sequence-specific DNA binding
- core promoter proximal region sequence-specific DNA binding
- transcription coactivator binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity
- DNA binding
- sequence-specific DNA binding transcription factor activity
- protein binding
- protein heterodimerization activity
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
- TFIID-class transcription factor binding
- Hsp90 protein binding
- TBP-class protein binding
- E-box binding