ATAD3B Gene Summary [Human]
The protein encoded by this gene is localized to the mitochondrial inner membrane, where it can bind to a highly-related protein, ATAD3A. ATAD3A appears to interact with matrix nucleoid complexes, and the encoded protein negatively regulates that interaction. This gene is expressed almost exclusively in pluripotent embryonic stem cells and some cancer cells. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]
Details
| Type | Protein Coding |
| Official Symbol | ATAD3B |
| Official Name | ATPase family AAA domain containing 3B [Source:HGNC Symbol;Acc:HGNC:24007] |
| Ensembl ID | ENSG00000160072 |
| Bio databases IDs | |
| Aliases | ATPase family AAA domain containing 3B |
| Synonyms | AAA-TOB3, ATPase family AAA domain containing 3B, TOB3 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ATAD3B often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- AAA domain (dynein-related subfamily)
- ATPase family associated with various cellular activities (AAA)
- Arginine and glutamate-rich 1
- MAP7 (E-MAP-115) family
- ATPase family AAA domain-containing protein 3, N-terminal
- P-loop containing Nucleoside Triphosphate Hydrolases
- ATPases associated with a variety of cellular activities
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Plasma Membrane
- Mitochondria
- secretory granule membrane
- nuclear scaffolds
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ATAD3B gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mitochondrion organization
Cellular Component
Where in the cell the gene product is active
- secretory granule membrane
- mitochondrion
- plasma membrane
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding