PAGR1 Gene Summary [Human]
Enables estrogen receptor binding activity. Involved in positive regulation of cell cycle G1/S phase transition; positive regulation of intracellular estrogen receptor signaling pathway; and positive regulation of transcription by RNA polymerase II. Located in nucleus. Part of MLL3/4 complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | PAGR1 |
| Official Name | PAXIP1 associated glutamate rich protein 1 [Source:HGNC Symbol;Acc:HGNC:28707] |
| Ensembl ID | ENSG00000280789 |
| Bio databases IDs | |
| Aliases | PAXIP1 associated glutamate rich protein 1, glutamate-rich coactivator interacting with SRC1/NCOA1, PTIP-associated 1 protein, glutamate-rich coactivator associated with SRC1 |
| Synonyms | 2900092E17Rik, C16orf53, C77040, GAS, PA1, Pagr1a, PAXIP1 associated glutamate rich protein 1, PAXIP1 associated glutamate rich protein 1A, RGD1305592 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PAGR1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- PAXIP1-associated-protein-1 C term PTIP binding protein
- estrogen receptor binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- growth failure
role in cell
- expression in
- binding in
- apoptosis
- adipogenesis
- cohesion in
- DNA damage response
- cohesion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PAGR1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA repair
- positive regulation of intracellular estrogen receptor signaling pathway
- DNA recombination
- positive regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- histone methyltransferase complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- estrogen receptor binding