PLPP7 Gene Summary [Human]
Predicted to enable sphingosine-1-phosphate phosphatase activity. Predicted to be involved in dephosphorylation. Predicted to act upstream of or within negative regulation of myotube differentiation. Predicted to be located in endoplasmic reticulum membrane. Predicted to be integral component of membrane. Predicted to be active in membrane and nuclear envelope. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | PLPP7 |
| Official Name | phospholipid phosphatase 7 (inactive) [Source:HGNC Symbol;Acc:HGNC:28174] |
| Ensembl ID | ENSG00000160539 |
| Bio databases IDs | |
| Aliases | phospholipid phosphatase 7 (inactive), nuclear envelope transmembrane protein NET39 |
| Synonyms | C9orf67, D830019K17RIK, NET39, phospholipid phosphatase 7 (inactive), PPAPDC3, RGD1305821 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PLPP7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Acid phosphatase homologues
- phosphatase
- PAP2_like
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear envelope
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PLPP7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of myotube differentiation
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- nuclear envelope
- membrane
Molecular Function
What the gene product does at the molecular level
- sphingosine-1-phosphate phosphatase activity