SUN2 Gene Summary [Human]
SUN1 (MIM 607723) and SUN2 are inner nuclear membrane (INM) proteins that play a major role in nuclear-cytoplasmic connection by formation of a 'bridge' across the nuclear envelope, known as the LINC complex, via interaction with the conserved luminal KASH domain of nesprins (e.g., SYNE1; MIM 608441) located in the outer nuclear membrane (ONM). The LINC complex provides a direct connection between the nuclear lamina and the cytoskeleton, which contributes to nuclear positioning and cellular rigidity (summary by Haque et al., 2010 [PubMed 19933576]).[supplied by OMIM, Nov 2010]
Details
| Type | Protein Coding |
| Official Symbol | SUN2 |
| Official Name | Sad1 and UNC84 domain containing 2 [Source:HGNC Symbol;Acc:HGNC:14210] |
| Ensembl ID | ENSG00000100242 |
| Bio databases IDs | |
| Aliases | Sad1 and UNC84 domain containing 2 |
| Synonyms | B230369L08Rik, C030011B15, FRIGG, rab5IP, RGD1563141, Sad1 and UNC84 domain containing 2, UNC84B |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SUN2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- microtubule binding
- coiled-coil domain 1 of SUN domain-containing proteins
- Sad1 / UNC-like C-terminal
- nuclear localization sequence
- protein binding activity, bridging
- lamin binding
- protein binding
- SUN2 helix-turn-helix domain
- identical protein binding
- Apolipoprotein A1/A4/E domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- alopecia
- hyperzincemia and hypercalprotectinemia autoinflammatory syndrome
- diverticular disease
- prostate cancer
- prostatic carcinoma
- ataxia
- cyanosis
role in cell
- apoptosis
- proliferation
- invasion by
- morphology
- quantity
- accumulation in
- activation in
- S phase
- migration
- formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear membrane fraction
- pH resistant lipid raft fraction
- Cytoplasm
- endosomes
- Endoplasmic Reticulum
- chromosome
- nuclear pores
- inner nuclear membrane
- spindle pole
- nuclear envelope
- telomeres
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SUN2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- centrosome localization
- nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration
- meiotic cell cycle
- mitotic spindle organization
- nuclear migration
- nuclear migration along microfilament
- nuclear matrix anchoring at nuclear membrane
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- nuclear envelope
- chromosome, telomeric region
- nuclear inner membrane
- nuclear membrane
- endosome membrane
- SUN-KASH complex
- condensed nuclear chromosome
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- protein anchor
- lamin binding
- microtubule binding