PM20D1 Gene Summary [Human]
Enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides. Involved in several processes, including amide biosynthetic process; cellular amide catabolic process; and negative regulation of neuron death. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | PM20D1 |
| Official Name | peptidase M20 domain containing 1 [Source:HGNC Symbol;Acc:HGNC:26518] |
| Ensembl ID | ENSG00000162877 |
| Bio databases IDs | |
| Aliases | peptidase M20 domain containing 1 |
| Synonyms | 4732466D17Rik, Cps1, FLJ32569, peptidase M20 domain containing 1, RGD1564063 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PM20D1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc peptidases M18, M20, M28, and M42
- linear amide carbon-nitrogen bond hydrolase
- Peptidase family M20/M25/M40
- peptidase
- acetylornithine deacetylase or succinyl-diaminopimelate desuccinylase
- succinyl-diaminopimelate desuccinylase, proteobacterial clade
- Peptidase dimerization domain
- N-acyl-L-amino-acid amidohydrolase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Extracellular Space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PM20D1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- amide biosynthetic process
- cellular amide catabolic process
- proteolysis
- energy homeostasis
- cellular lipid metabolic process
- cellular amino acid metabolic process
- fatty acid metabolic process
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- extracellular region
Molecular Function
What the gene product does at the molecular level
- hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
- metal ion binding
- lyase activity
- peptidase activity
- aminoacylase activity