SLC15A2 Gene Summary [Human]
The mammalian kidney expresses a proton-coupled peptide transporter that is responsible for the absorption of small peptides, as well as beta-lactam antibiotics and other peptide-like drugs, from the tubular filtrate. This transporter, SLC15A2, belongs to the same gene family as SLC15A1 (MIM 600544), the proton-coupled peptide transporter found in the small intestine (Liu et al, 1995 [PubMed 7756356]).[supplied by OMIM, Feb 2011]
Details
| Type | Protein Coding |
| Official Symbol | SLC15A2 |
| Official Name | solute carrier family 15 member 2 [Source:HGNC Symbol;Acc:HGNC:10921] |
| Ensembl ID | ENSG00000163406 |
| Bio databases IDs | |
| Aliases | solute carrier family 15 member 2 |
| Synonyms | 8430408C16Rik, FLJ33407, PEPT2, solute carrier family 15 (H+/peptide transporter), member 2, solute carrier family 15 member 2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SLC15A2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- amide transporter
- high affinity oligopeptide transporter
- transmembrane domain
- Major Facilitator Superfamily
- peptide:hydrogen symporter
- protein binding
- tripeptide transporter
- peptide:H+ symporter family
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Alzheimer disease
- proximal tubular toxicity
- endometriosis
- allergic rhinitis
- multiple sclerosis
- eczema
- allergy
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- apical cell surfaces
- apical membrane
- brush border
- brush border membrane vesicles
- phagosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SLC15A2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ion transport
- renal absorption
- dipeptide transport
- protein transport
- regulation of nucleotide-binding oligomerization domain containing signaling pathway
- xenobiotic transport
- peptidoglycan transport
- peptide transport
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- membrane
- phagocytic vesicle membrane
- apical plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- dipeptide transmembrane transporter activity
- peptide:hydrogen symporter activity
- protein binding
- tripeptide transporter activity