EGR3 Gene Summary [Human]
This gene encodes a transcriptional regulator that belongs to the EGR family of C2H2-type zinc-finger proteins. It is an immediate-early growth response gene which is induced by mitogenic stimulation. The protein encoded by this gene participates in the transcriptional regulation of genes in controling biological rhythm. It may also play a role in a wide variety of processes including muscle development, lymphocyte development, endothelial cell growth and migration, and neuronal development. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Dec 2010]
Details
| Type | Protein Coding |
| Official Symbol | EGR3 |
| Official Name | early growth response 3 [Source:HGNC Symbol;Acc:HGNC:3240] |
| Ensembl ID | ENSG00000179388 |
| Bio databases IDs | |
| Aliases | early growth response 3, zinc finger protein pilot |
| Synonyms | early growth response 3, PILOT |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human EGR3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc finger, C2H2 type
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- zinc finger
- Early growth response N-terminal domain
- transcription regulator
- double-stranded DNA binding
- Zinc-finger double domain
- zinc finger domain
- sequence-specific DNA binding
- transcription factor activity
- C2H2-type zinc finger
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- cancer
- resting tremor
- autoimmune disease
- gait disturbance
- endometrioid cancer
- glioblastoma
- glioblastoma cancer
- systemic lupus erythematosus
- COVID-19
role in cell
- migration
- expression in
- proliferation
- production in
- activation
- apoptosis
- activation in
- expansion
- morphology
- number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- nucleoplasm
- chromatin
- axons
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human EGR3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of T cell differentiation in thymus
- neuromuscular synaptic transmission
- cellular response to fibroblast growth factor stimulus
- peripheral nervous system development
- cell migration involved in sprouting angiogenesis
- regulation of gamma-delta T cell differentiation
- positive regulation of transcription from RNA polymerase II promoter
- circadian rhythm
- regulation of transcription from RNA polymerase II promoter
- muscle organ development
- negative regulation of apoptotic process
- endothelial cell chemotaxis
- cellular response to vascular endothelial growth factor stimulus
- positive regulation of endothelial cell proliferation
Cellular Component
Where in the cell the gene product is active
- synapse
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- sequence-specific DNA binding transcription factor activity
- metal ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity