ADAM29 Gene Summary [Human]

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene is highly expressed in testis and may be involved in human spermatogenesis. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Jul 2008]

Details

Type
Processed Transcript
Official Symbol
ADAM29
Official Name
ADAM metallopeptidase domain 29 [Source:HGNC Symbol;Acc:HGNC:207]
Ensembl ID
ENSG00000168594
Bio databases IDs NCBI: 11086 Ensembl: ENSG00000168594
Aliases ADAM metallopeptidase domain 29, cancer/testis antigen 73
Synonyms Adam20, Adam21, ADAM metallopeptidase domain 21, ADAM metallopeptidase domain 29, a disintegrin and metallopeptidase domain 29, CT73, LOC108348202, RGD1562912, svph1
Species
Human, Homo sapiens
OrthologiesMouseRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ADAM29 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • Myxococcus cysteine-rich repeat
  • Reprolysin family propeptide
  • metallopeptidase
  • Mucin-like
  • ZnMc
  • ADAM cysteine-rich
  • Metallo-peptidase family M12B Reprolysin-like
  • peptidase
  • Disintegrin
  • Reprolysin (M12B) family zinc metalloprotease
  • Proline-rich protein
  • Domain of unknown function (DUF1720)

Pathways

Biological processes and signaling networks where the ADAM29 gene in human plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
disease
  • ovarian carcinoma
  • epithelial ovarian cancer
  • breast carcinoma
regulated by

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Plasma Membrane
  • cellular membrane
  • plasma membrane extracellular face
  • neurites
  • perikaryon
  • axons

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human ADAM29 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • male gonad development
  • spermatogenesis
  • proteolysis

Cellular Component

Where in the cell the gene product is active
  • external side of plasma membrane
  • plasma membrane

Molecular Function

What the gene product does at the molecular level
  • metalloendopeptidase activity
  • metallopeptidase activity

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.