ZFPM2 Gene Summary [Human]
The zinc finger protein encoded by this gene is a widely expressed member of the FOG family of transcription factors. The family members modulate the activity of GATA family proteins, which are important regulators of hematopoiesis and cardiogenesis in mammals. It has been demonstrated that the protein can both activate and down-regulate expression of GATA-target genes, suggesting different modulation in different promoter contexts. A related mRNA suggests an alternatively spliced product but this information is not yet fully supported by the sequence. [provided by RefSeq, Jul 2008]
Details
| Type | Processed Transcript |
| Official Symbol | ZFPM2 |
| Official Name | zinc finger protein, FOG family member 2 [Source:HGNC Symbol;Acc:HGNC:16700] |
| Ensembl ID | ENSG00000169946 |
| Bio databases IDs | |
| Aliases | zinc finger protein, FOG family member 2 |
| Synonyms | B330005D23Rik, DIH3, FOG-2, hFOG-2, SRXY9, ZC2HC11B, zinc finger protein, FOG family member 2, zinc finger protein, multitype 2, ZNF89B |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ZFPM2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- transcription co-activator
- SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily
- transcription co-repressor
- transcription factor binding
- protein binding
- zinc finger domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- non-insulin-dependent diabetes mellitus
- hypertension
- cardiovascular disorder
- edema
- bleeding
- myocardial infarction
- atrial septal defect
- dry eye syndrome
- coronary artery disease
role in cell
- expression in
- proliferation
- activation in
- phosphorylation in
- differentiation
- erythropoiesis
- glycogenesis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ZFPM2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of cardiac muscle cell proliferation
- positive regulation of male gonad development
- negative regulation of female gonad development
- negative regulation of fat cell differentiation
- embryonic organ development
- vasculogenesis
- fat cell differentiation
- right ventricular cardiac muscle tissue morphogenesis
- positive regulation of transcription from RNA polymerase II promoter
- ventricular septum morphogenesis
- gonadal mesoderm development
- negative regulation of transcription from RNA polymerase II promoter
- outflow tract septum morphogenesis
- heart development
- negative regulation of transcription, DNA-dependent
- in utero embryonic development
- cell differentiation
- lung development
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- chromatin
- male germ cell nucleus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- zinc ion binding
- protein binding
- transcription coactivator activity
- transcription corepressor activity