Zfpm2 Gene Summary [Mouse]
Enables transcription corepressor activity. Involved in several processes, including negative regulation of female gonad development; positive regulation of cardiac muscle cell proliferation; and positive regulation of male gonad development. Acts upstream of or within several processes, including circulatory system development; in utero embryonic development; and regulation of transcription by RNA polymerase II. Located in cytoplasm and male germ cell nucleus. Is expressed in several structures, including brain; embryo mesenchyme; genitourinary system; gut; and heart and pericardium. Used to study congenital diaphragmatic hernia; tetralogy of Fallot; and tricuspid atresia. Human ortholog(s) of this gene implicated in 46,XY sex reversal 9; congenital diaphragmatic hernia; myelodysplastic syndrome; and tetralogy of Fallot. Orthologous to human ZFPM2 (zinc finger protein, FOG family member 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Zfpm2 |
| Official Name | zinc finger protein, multitype 2 [Source:MGI Symbol;Acc:MGI:1334444] |
| Ensembl ID | ENSMUSG00000022306 |
| Bio databases IDs | |
| Aliases | zinc finger protein, multitype 2 |
| Synonyms | B330005D23Rik, DIH3, FOG-2, hFOG-2, SRXY9, ZC2HC11B, zinc finger protein, FOG family member 2, zinc finger protein, multitype 2, ZNF89B |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Zfpm2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- transcription co-activator
- SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily
- transcription co-repressor
- transcription factor binding
- protein binding
- zinc finger domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- non-insulin-dependent diabetes mellitus
- hypertension
- cardiovascular disorder
- edema
- bleeding
- myocardial infarction
- atrial septal defect
- dry eye syndrome
- coronary artery disease
role in cell
- expression in
- proliferation
- activation in
- phosphorylation in
- differentiation
- erythropoiesis
- glycogenesis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Zfpm2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of cardiac muscle cell proliferation
- positive regulation of male gonad development
- negative regulation of female gonad development
- negative regulation of fat cell differentiation
- embryonic organ development
- vasculogenesis
- fat cell differentiation
- right ventricular cardiac muscle tissue morphogenesis
- positive regulation of transcription from RNA polymerase II promoter
- ventricular septum morphogenesis
- gonadal mesoderm development
- negative regulation of transcription from RNA polymerase II promoter
- outflow tract septum morphogenesis
- heart development
- negative regulation of transcription, DNA-dependent
- in utero embryonic development
- cell differentiation
- lung development
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- chromatin
- male germ cell nucleus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- zinc ion binding
- protein binding
- transcription coactivator activity
- transcription corepressor activity