CEACAM3 Gene Summary [Human]
This gene encodes a member of the family of carcinoembryonic antigen-related cell adhesion molecules (CEACAMs), which are used by several bacterial pathogens to bind and invade host cells. The encoded transmembrane protein directs phagocytosis of several bacterial species that is dependent on the small GTPase Rac. It is thought to serve an important role in controlling human-specific pathogens by the innate immune system. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2013]
Details
| Type | Protein Coding |
| Official Symbol | CEACAM3 |
| Official Name | CEA cell adhesion molecule 3 [Source:HGNC Symbol;Acc:HGNC:1815] |
| Ensembl ID | ENSG00000170956 |
| Bio databases IDs | |
| Aliases | CEA cell adhesion molecule 3 |
| Synonyms | CD66D, CEA, CEA cell adhesion molecule 3, CGM1, CGM1a, W264, W282 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CEACAM3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- itam like domain
- cytoplasmic domain
- immunoglobulin domain
- protein binding
- Immunoglobulin V-set domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- dementia
- acute myeloid leukemia
role in cell
- binding
- cell death
- activation
- phagocytosis
- engulfment
- internalization
- phagocytosis by
- internalization by
- reorganization
- adhesion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- cellular membrane
- Plasma Membrane
- specific granule membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CEACAM3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- regulation of immune system process
Cellular Component
Where in the cell the gene product is active
- plasma membrane
- cell surface
- specific granule membrane
Molecular Function
What the gene product does at the molecular level
- protein binding