CEACAM5 Gene Summary [Human]
This gene encodes a cell surface glycoprotein that represents the founding member of the carcinoembryonic antigen (CEA) family of proteins. The encoded protein is used as a clinical biomarker for gastrointestinal cancers and may promote tumor development through its role as a cell adhesion molecule. Additionally, the encoded protein may regulate differentiation, apoptosis, and cell polarity. This gene is present in a CEA family gene cluster on chromosome 19. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]
Details
| Type | Protein Coding |
| Official Symbol | CEACAM5 |
| Official Name | CEA cell adhesion molecule 5 [Source:HGNC Symbol;Acc:HGNC:1817] |
| Ensembl ID | ENSG00000105388 |
| Bio databases IDs | |
| Aliases | CEA cell adhesion molecule 5 |
| Synonyms | carcinoembryonic antigen, CD66e, CEA, CEA cell adhesion molecule 5 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CEACAM5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- lipid binding
- immunoglobulin domain
- Ig-like C2 domain
- Immunoglobulin I-set domain
- protein binding
- identical protein binding
- phosphatidylinositol binding
- binding protein
- Immunoglobulin like
- protein homodimerization
- glycosylphosphatidylinositol anchor sequence
- Immunoglobulin V-set domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- colitis
- non-squamous non-small cell lung cancer
- lung adenocarcinoma
- lung adenocarcinoma formation
- breast cancer
- organismal death
- gastric cancer
- edema
- colorectal cancer
role in cell
- proliferation
- expression in
- migration
- binding in
- phosphorylation in
- apoptosis
- differentiation
- survival
- binding
- activation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- Extracellular Space
- microvesicles
- cellular membrane
- apical membrane
- basolateral membrane
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CEACAM5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of anoikis
- negative regulation of apoptotic process
- apoptotic process
- heterophilic cell-cell adhesion
- homophilic cell adhesion
- negative regulation of myotube differentiation
- homotypic cell-cell adhesion
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- membrane
- extracellular region
- basolateral plasma membrane
- apical plasma membrane
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- protein homodimerization activity
- GPI anchor binding