NINJ1 Gene Summary [Human]
The ninjurin protein is upregulated after nerve injury both in dorsal root ganglion neurons and in Schwann cells (Araki and Milbrandt, 1996 [PubMed 8780658]). It demonstrates properties of a homophilic adhesion molecule and promotes neurite outgrowth from primary cultured dorsal root ganglion neurons.[supplied by OMIM, Aug 2009]
Details
| Type | Protein Coding |
| Official Symbol | NINJ1 |
| Official Name | ninjurin 1 [Source:HGNC Symbol;Acc:HGNC:7824] |
| Ensembl ID | ENSG00000131669 |
| Bio databases IDs | |
| Aliases | ninjurin 1, nerve injury-induced protein-1 |
| Synonyms | hNINJ1, NIN1, NINJURIN, ninjurin 1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NINJ1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ninjurin
- homophilic binding domain
- cell adhesion molecule binding
- protein binding
- lipopolysaccharide binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial neoplasia
- benign neoplasia
- neoplasia
- obesity
- cancer
- epithelial cancer
- non-small cell lung cancer
- COVID-19
- gout
- T-cell non-Hodgkin disease
role in cell
- migration
- expression in
- formation
- formation in
- growth
- proliferation
- apoptosis
- quantity
- cellular infiltration
- function
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Extracellular Space
- cellular membrane
- synaptic membrane
- plasma membrane projections
- filopodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NINJ1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of toll-like receptor 4 signaling pathway
- positive regulation of inflammatory response
- protein homooligomerization
- nervous system development
- cell adhesion
- tissue regeneration
- leukocyte chemotaxis involved in inflammatory response
- positive regulation of angiogenesis
- angiogenesis
- muscle cell differentiation
- killing of cells of other organism
- pyroptosis
- heterotypic cell-cell adhesion
- programmed cell death
Cellular Component
Where in the cell the gene product is active
- synaptic membrane
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- lipopolysaccharide binding