PARP15
PARP15 Gene Summary
Enables NAD+ binding activity; pentosyltransferase activity; and transcription corepressor activity. Involved in negative regulation of transcription by RNA polymerase II; protein mono-ADP-ribosylation; and protein poly-ADP-ribosylation. Predicted to be active in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | PARP15 |
| Official Name | poly(ADP-ribose) polymerase family member 15 [Source:HGNC Symbol;Acc:HGNC:26876] |
| Ensembl ID | ENSG00000173200 |
| Bio databases IDs | |
| Aliases | poly(ADP-ribose) polymerase family member 15 |
| Synonyms | ARTD7,BAL3,FLJ40597,pART7,poly(ADP-ribose) polymerase family member 15 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- macro domain
- NAD or NADH binding
- binding protein
- pentosyltransferase
- NAD ADP-ribosyltransferase
- macrodomain superfamily
- transcription co-repressor
- Poly(ADP-ribose) polymerase catalytic domain
- enzyme
- protein binding
- ADP_ribosyl
Pathways
Biological processes and signaling networks where the PARP15 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- APP
- NRM
- YTHDC1
disease
- major depression
- Alzheimer disease
- periodontitis
regulated by
regulates
- DNA endogenous promoter
- DNA promoter
- RNA polymerase II
role in cell
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the PARP15 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- negative regulation of gene expression
- protein poly-ADP-ribosylation
CELLULAR COMPONENT
Where in the cell the gene product is active
- nucleus
- cytoplasm
MOLECULAR FUNCTION
What the gene product does at the molecular level
- nucleotidyltransferase activity
- protein binding
- transcription corepressor activity
- NAD+ binding
- NAD+ ADP-ribosyltransferase activity