MARCHF10 Gene Summary [Human]
MARCH10 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments (Morokuma et al., 2007 [PubMed 17604280]).[supplied by OMIM, Apr 2010]
Details
| Type | Processed Transcript |
| Official Symbol | MARCHF10 |
| Official Name | membrane associated ring-CH-type finger 10 [Source:HGNC Symbol;Acc:HGNC:26655] |
| Ensembl ID | ENSG00000173838 |
| Bio databases IDs | |
| Aliases | membrane associated ring-CH-type finger 10 |
| Synonyms | 4933417C16RIK, AV039223, MARCH10, MARCH-X, membrane associated ring-CH-type finger 10, RGD1311692, RNF190 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MARCHF10 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ring like zinc finger domain
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- annulus
- microtubules
- sperm tail
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MARCHF10 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein ubiquitination
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding
- transferase activity