GCNT4 Gene Summary [Human]
Predicted to enable acetylglucosaminyltransferase activity. Predicted to be involved in O-glycan processing and carbohydrate metabolic process. Predicted to act upstream of or within several processes, including inter-male aggressive behavior; kidney morphogenesis; and thyroid hormone metabolic process. Predicted to be located in Golgi membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | GCNT4 |
| Official Name | glucosaminyl (N-acetyl) transferase 4 [Source:HGNC Symbol;Acc:HGNC:17973] |
| Ensembl ID | ENSG00000176928 |
| Bio databases IDs | |
| Aliases | glucosaminyl (N-acetyl) transferase 4, core 2 beta-1,6-N-acetylglucosaminyltransferase 3, beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 4 |
| Synonyms | C2GNT3, glucosaminyl (N-acetyl) transferase 4, glucosaminyl (N-acetyl) transferase 4, core 2 (beta-1,6-N-acetylglucosaminyltransferase), glucosaminyl (N-acetyl) transferase 4, core 2 (β-1,6-N-acetylglucosaminyltransferase), Gm279, Gm73, LINC01336, RGD1563891 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GCNT4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Core-2/I-Branching enzyme
- N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase
- beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase
- enzyme
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Golgi membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GCNT4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- carbohydrate metabolic process
- kidney morphogenesis
- tissue morphogenesis
- protein O-linked glycosylation
- O-glycan processing
- inter-male aggressive behavior
- neutrophil homeostasis
- thyroid hormone metabolic process
Cellular Component
Where in the cell the gene product is active
- Golgi membrane
Molecular Function
What the gene product does at the molecular level
- N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity
- acetylglucosaminyltransferase activity
- beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity