GSTA5 Gene Summary [Human]
The glutathione S-transferases (GST; EC 2.5.1.18) catalyze the conjugation of reduced glutathiones and a variety of electrophiles, including many known carcinogens and mutagens. The cytosolic GSTs belong to a large superfamily, with members located on different chromosomes. For additional information on GSTs, see GSTA1 (MIM 138359).[supplied by OMIM, Sep 2008]
Details
| Type | Protein Coding |
| Official Symbol | GSTA5 |
| Official Name | glutathione S-transferase alpha 5 [Source:HGNC Symbol;Acc:HGNC:19662] |
| Ensembl ID | ENSG00000182793 |
| Bio databases IDs | |
| Aliases | glutathione S-transferase alpha 5 |
| Synonyms | glutathione S-transferase alpha 5, glutathione S-transferase α 5 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GSTA5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Glutathione S-transferase, C-terminal domain
- C-terminal, alpha helical domain of the Glutathione S-transferase family
- Glutathione S-transferase, N-terminal domain
- glutathione transferase
- Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
- enzyme
- protein binding
Pathways
Biological processes and signaling networks where the GSTA5 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GSTA5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- glutathione metabolic process
- xenobiotic metabolic process
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- glutathione transferase activity