EIF3M Gene Summary [Human]
This gene encodes a protein that is part of the eurkaryotic translation initiation factor 3 complete (eIF-3) required for protein synthesis. Elevated levels of the encoded protein are present in cancer cell lines. Inactivation of the encoded protein has been shown to interfere with translation of herpes virus mRNAs by preventing the association of mRNAs with the ribosomes. A pseudogene of this gene is located on the X chromosome. [provided by RefSeq, Dec 2011]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | EIF3M |
| Official Name | eukaryotic translation initiation factor 3 subunit M [Source:HGNC Symbol;Acc:HGNC:24460] |
| Ensembl ID | ENSG00000149100 |
| Bio databases IDs | |
| Aliases | eukaryotic translation initiation factor 3 subunit M, transport and golgi organization 7 homolog (Drosophila) |
| Synonyms | B5, Dendritic cell protein ga17, eukaryotic translation initiation factor 3 subunit M, eukaryotic translation initiation factor 3, subunit M, GA17, hfl-B5, PCID1, RGD1565840, TANGO7 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human EIF3M often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- motif in proteasome subunits, Int-6, Nip-1 and TRIP-15
- PCI domain
- translation initiation factor
- eIF3 subunit M, C-terminal helix
- protein binding
- translation regulator
Pathways
Biological processes and signaling networks where the EIF3M gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colon cancer
- inguinal hernia
role in cell
- expression in
- apoptosis
- proliferation
- cell cycle progression
- translation in
- stabilization in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- multicilium
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human EIF3M gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- formation of translation initiation complex
- cytoplasmic translational initiation
- translational initiation
Cellular Component
Where in the cell the gene product is active
- eukaryotic translation initiation factor 3 complex, eIF3m
- eukaryotic 43S preinitiation complex
- cytosol
- eukaryotic 48S preinitiation complex
- eukaryotic translation initiation factor 3 complex
Molecular Function
What the gene product does at the molecular level
- translation initiation factor activity
- protein binding
- translation initiation factor binding