IFNGR1 Gene Summary [Human]
This gene (IFNGR1) encodes the ligand-binding chain (alpha) of the gamma interferon receptor. Human interferon-gamma receptor is a heterodimer of IFNGR1 and IFNGR2. A genetic variation in IFNGR1 is associated with susceptibility to Helicobacter pylori infection. In addition, defects in IFNGR1 are a cause of mendelian susceptibility to mycobacterial disease, also known as familial disseminated atypical mycobacterial infection. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | IFNGR1 |
| Official Name | interferon gamma receptor 1 [Source:HGNC Symbol;Acc:HGNC:5439] |
| Ensembl ID | ENSG00000027697 |
| Bio databases IDs | |
| Aliases | interferon gamma receptor 1 |
| Synonyms | CD119, Ifgr, IFN-gammaR, IFN gamma R alpha, IFN-gamma receptor, IFNGR, Ifngra, IFN-γR1, IFN-γ receptor, IFN γ R α, IMD27A, IMD27B, interferon gamma receptor 1, INTERFERON gamma receptor alpha CHAIN, interferon γ receptor, interferon γ receptor 1, INTERFERON γ receptor α CHAIN, MAF receptor, Nktar |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human IFNGR1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- STAT binding domain
- extracellular domain
- STAT1 binding domain
- cytoplasmic domain
- interferon-gamma receptor
- transmembrane domain
- intracellular domain
- protein binding
- membrane-proximal domain
- Interferon-alpha/beta receptor, fibronectin type III
- Tissue factor
- transmembrane receptor
Pathways
Biological processes and signaling networks where the IFNGR1 gene in human plays a role, providing insight into its function and relevance in health or disease.
- Airway Inflammation in Asthma
- Colorectal Cancer Metastasis Signaling
- Hepatic Fibrosis / Hepatic Stellate Cell Activation
- HMGB1 Signaling
- IL-10 Signaling
- IL-12 Signaling and Production in Macrophages
- iNOS Signaling
- Interferon Signaling
- Neuroinflammation Signaling Pathway
- Production of Nitric Oxide and Reactive Oxygen Species in Macrophages
- Role of JAK1, JAK2 and TYK2 in Interferon Signaling
- Role of PKR in Interferon Induction and Antiviral Response
- T Helper Cell Differentiation
- Th1 and Th2 Activation Pathway
- Th1 Pathway
- Type I Diabetes Mellitus Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- metastasis
- cancer
- tumorigenesis
- diabetes mellitus
- kidney disease
- infection by murine hepatitis virus
- lupus erythematosus
- autosomal recessive mycobacteriosis immunodeficiency 27A
- insulitis
role in cell
- adhesion
- activation in
- expression in
- phosphorylation in
- growth
- formation
- proliferation
- quantity
- apoptosis
- production in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- detergent-insoluble fractions
- Cytoplasm
- cell surface
- cell periphery
- membrane surface
- cellular membrane
- vesicles
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human IFNGR1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- astrocyte activation
- microglial cell activation
- interferon-gamma-mediated signaling pathway
- signal transduction
- cytokine-mediated signaling pathway
- positive regulation of gene expression
- negative regulation of beta-amyloid clearance
- positive regulation of tumor necrosis factor production
- response to virus
Cellular Component
Where in the cell the gene product is active
- membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- interferon-gamma receptor activity
- cytokine binding
- cytokine receptor activity