SGCZ Gene Summary [Human]
The zeta-sarcoglycan gene measures over 465 kb and localizes to 8p22. This protein is part of the sarcoglycan complex, a group of 6 proteins. The sarcoglycans are all N-glycosylated transmembrane proteins with a short intra-cellular domain, a single transmembrane region and a large extra-cellular domain containing a carboxyl-terminal cluster with several conserved cysteine residues. The sarcoglycan complex is part of the dystrophin-associated glycoprotein complex (DGC), which bridges the inner cytoskeleton and the extra-cellular matrix. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | SGCZ |
| Official Name | sarcoglycan zeta [Source:HGNC Symbol;Acc:HGNC:14075] |
| Ensembl ID | ENSG00000185053 |
| Bio databases IDs | |
| Aliases | sarcoglycan zeta, Zeta-sarcoglycan, Zeta-SG |
| Synonyms | C230085N17Rik, sarcoglycan zeta, sarcoglycan ζ, ZSG1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SGCZ often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Sarcoglycan complex subunit protein
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hypertension
- acute myeloid leukemia
- Huntington disease
- insomnia
- idiopathic scoliosis
- non-insulin-dependent diabetes mellitus
- neuroticism
- differentiated thyroid carcinoma
- major depression
- splenomegaly
regulated by
role in cell
- development
- homeostasis
- organization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- endoplasmic reticulum membrane
- Golgi membrane
- sarcolemma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SGCZ gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- membrane organization
- muscle cell homeostasis
- heart contraction
- muscle cell development
- cardiac muscle tissue development
Cellular Component
Where in the cell the gene product is active
- cytoskeleton
- cytoplasm
- sarcolemma
- sarcoglycan complex