CYP4F12 Gene Summary [Human]
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein likely localizes to the endoplasmic reticulum. When expressed in yeast the enzyme is capable of oxdizing arachidonic acid. It can also catalyze the epoxidation of 22:6n-3 and 22:5n-3 polyunsaturated long-chain fatty acids. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]
Details
| Type | Protein Coding |
| Official Symbol | CYP4F12 |
| Official Name | cytochrome P450 family 4 subfamily F member 12 [Source:HGNC Symbol;Acc:HGNC:18857] |
| Ensembl ID | ENSG00000186204 |
| Bio databases IDs | |
| Aliases | cytochrome P450 family 4 subfamily F member 12 |
| Synonyms | CYPIVF12, cytochrome P450 family 4 subfamily F member 12, F22329 1 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CYP4F12 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cytochrome P450 (CYP) superfamily
- Cytochrome P450
- leukotriene-B4 20-monooxygenase
- monooxygenase
- enzyme
- protein binding
- arachidonic acid epoxygenase
- alkane 1-monooxygenase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- endoplasmic reticulum membrane
- apical membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CYP4F12 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- leukotriene B4 catabolic process
- renal water homeostasis
- sodium ion homeostasis
- pressure natriuresis
- phylloquinone catabolic process
- very long-chain fatty acid metabolic process
- fatty acid metabolic process
- long-chain fatty acid metabolic process
- epoxygenase P450 pathway
- vitamin E metabolic process
- menaquinone catabolic process
- xenobiotic metabolic process
- arachidonic acid metabolic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- cytoplasm
- intracellular membrane-bounded organelle
- apical plasma membrane
Molecular Function
What the gene product does at the molecular level
- arachidonic acid epoxygenase activity
- protein binding
- iron ion binding
- aromatase activity
- leukotriene-B4 20-monooxygenase activity
- alkane 1-monooxygenase activity
- monooxygenase activity
- heme binding